Doxycycline-Mediated Inhibition of Choroidal Neovascularization
نویسندگان
چکیده
منابع مشابه
IKK2 Inhibition Attenuates Laser-Induced Choroidal Neovascularization
Choroidal neovascularization (CNV) is aberrant angiogenesis associated with exudative age-related macular degeneration (AMD), a leading cause of blindness in the elderly. Inflammation has been suggested as a risk factor for AMD. The IKK2/NF-κB pathway plays a key role in the inflammatory response through regulation of the transcription of cytokines, chemokines, growth factors and angiogenic fac...
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Placental growth factor (PlGF) is a member of the vascular endothelial growth factor (VEGF) family of angiogenesis factors. It has the highest expression level in the endothelium as compared to other VEGF family members and plays an important role in pathological neovascularization. 1 In humans, four isoforms of PlGF exist (PlGF-1 through 4). Mice only express a single isoform of PlGF which is ...
متن کاملInhibition of choroidal neovascularization by homoisoflavanone, a new angiogenesis inhibitor
PURPOSE Age-related macular degeneration (AMD) is the leading cause of blindness in elderly. The detailed mechanism of choroidal neovascularization (CNV) leads to severe vision loss in patients with AMD. This study was undertaken to evaluate the inhibitory effect of homoisoflavanone on CNV. METHODS Antiangiogenic activity of homoisoflavanone was evaluated by in vitro tube formation assay of h...
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The aim of this study was to determine the effect of the EphB4 monoclonal antibody on experimental choroidal neovascularization (CNV) progression. Experimental CNV was established by argon laser photocoagulation. In the experimental group, the EphB4 monoclonal antibody was injected into the vitreous space in the eye specimens on days 0, 3, 6 and 9 after CNV model establishment. In the control g...
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Choroidal neovascularization (CNV) is the defining characteristic feature of the wet subtype of age-related macular degeneration (AMD) and may result in irreversible blindness. Based on anti-vascular endothelial growth factor (anti-VEGF), the current therapeutic approaches to CNV are fraught with difficulties, and mammalian target of rapamycin (mTOR) has recently been proposed as a possible the...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2009
ISSN: 1552-5783
DOI: 10.1167/iovs.08-3174